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An Analysis and Comparison of Quality Index Using Clustering Techniques for Spot Detection in Noisy Microarray Images
A. Sri Nagesh, G.P.Saradhi Varma, A.Govardhan, B.Raveendra Babu
Pages - 504 - 511     |    Revised - 01-09-2011     |    Published - 05-10-2011
Volume - 5   Issue - 4    |    Publication Date - September / October 2011  Table of Contents
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KEYWORDS
Microarray Image, Genes, Spot Segmentation, Morphological Operator, Fuzzy K-Means, Fuzzy C-means, Enhanced fuzzy C-means Clustering (EFCM).
ABSTRACT
In this paper, the proposed approach consists of mainly three important steps: preprocessing, gridding and segmentation of micro array images. Initially, the microarray image is preprocessed using filtering and morphological operators and it is given for gridding to fit a grid on the images using hill-climbing algorithm. Subsequently, the segmentation is carried out using the fuzzy c-means clustering. Initially the enhanced fuzzy c-means clustering algorithm (EFCMC) is implemented to effectively clustering the image whether the image may be affected by the noises or not. Then, the EFCM method was employed the real microarray images and noisy microarray images in order to investigate the efficiency of the segmentation. Finally, the segmentation efficiency of the proposed approach was compared with the various algorithms in terms of quality index and the obtained results ensures that the performance efficiency of the proposed algorithm was improved in term of quality index rather than other algorithms.
1 Google Scholar 
2 CiteSeerX 
3 refSeek 
4 Scribd 
5 SlideShare 
6 PdfSR 
A.Sri Nagesh, Dr G.P.S.Varma, Dr.A.Govardhan “An Improved Iterative Watershed and Morphological Transformation Techniques for Segmentation of Microarray Images” IJCA Special Issue on “Computer Aided Soft Computing Techniques for Imaging and Biomedical Applications” CASCT, 2010.
A.Sri Nagesh, Dr.A.Govardhan,Dr G.P.S.Varma, Dr G.S.Prasad, ”An Automated Histogram Equalized Fuzzy Clustering based Approach for the Segmentation of Microarray images.”ANU Journal of Engineering and Technology, pp 42-48 volume 2, Issue 2 December 2010, ISSN: 0976-3414.
Ergüt E, Yardimci Y, Mumcuoglu E, Konu O. "Analysis of microarray images using FCM and K-means clustering algorithm", In: Proceedings of International Conference on Signal Processing, p. 116–21, 2003.
Kaushik Suresh, Debarati Kundu, Sayan Ghosh, Swagatam Das, Ajith Abraham and Sang Yong Han, "Multi-Objective Differential Evolution for Automatic Clustering with Application to Micro-Array Data Analysis", Sensors, Vol. 9, pp. 3981-4004, 2009.
Laurie Heyer, “MicroArray Genome Imaging & Clustering (MAGIC) Tool”, Davidson College, Available: http://www.bio.davidson.edu/projects/magic/magic.html
Luis Rueda, Juan Carlos Rojas, "A Pattern Classification Approach to DNA Microarray Image Segmentation", in Proceedings of the 4th IAPR International Conference on Pattern Recognition in Bioinformatics, 2009.
Maroulis D., Zacharia, E., "Microarray image segmentation using spot morphological model", in proceedings of the 9th International Conference on information Technology and Applications in Biomedicine, Larnaca, pp: 1-4, 2009.
Sebastiano Battiato, Gianpiero Di Blasi, Giovanni Maria Farinella, Giovanni Gallo and Giuseppe Claudio Guarnera, “Adaptive techniques for microarray image analysis with related quality assessment”, vo. 16, no.4, 2007.
U. Sauer, C. Preininger, and S. R. Hany, “Quick & simple: quality control of microarray data”, Bioinformatics, Advance Access, 2004.
Volkan Uslan and ðhsan Ömür Bucak, "Microarray Image Segmentation Using Clustering Methods", Mathematical and Computational Applications, Vol. 15, No. 2, pp. 240-247, 2010.
Wu, H., Yan, H., “Microarray Image Processing Based on Clustering and Morphological Analysis”, In First Asia Pacific Bioinformatics Conference, 111-118, 2003.
“Microarray Images”, from http://llmpp.nih.gov/lymphoma/data/rawdata/
Mr. A. Sri Nagesh
- India
asrinagesh@gmail.com
Mr. G.P.Saradhi Varma
- India
Mr. A.Govardhan
- India
Mr. B.Raveendra Babu
- India